According to the American Medical Association's (AMA) Handbook of Poisonous and Injurous Plants, eating large amounts of apple seeds (and other seeds) can be fatal. The culprit: cyanogenic glycoside or cyanide. Some fruits known for seeds that contain cyanide include apples, cherries, apricots, nectarines, peaches, and plums.
I usually enjoy my seed swallowing binge with the lanzones, watermelon, apple, and citrus fruits. Haven't found reliable information regarding the lanzones (the seeds in particular) toxicity but it's hard to overlook the AMA handbook's "and other seeds" line.
I haven't encountered the following symptoms yet...
- excessive sweating
- abdonminal pain
- vomiting
- lethargy
...so I'm quite sure I haven't accumulated enough poison inside my powerful gut yet. I have been warned, though.
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